Levitra (vardenafil) Info

Erectile dysfunction (ED) is a highly prevalent condition that has a major impact on the lives of millions of men and their partners, affecting sexual and psychological health and quality of life (QOL). Depending on the etiology, ED may indicate underlying systemic vascular or neurogenic disease that is often associated with the impairment of neurogenic and/or endothelium-dependent vasodilatory mechanisms, which in turn contribute to circulatory and structural changes in penile tissues. The resulting arterial insufficiency and defective smooth muscle relaxation in men with vascular comorbidities lead to an increased prevalence of ED in this patient population, which complicates disease management.

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The present study showed that administering vardenafil at reperfusion decreased infarct size in rat isolated hearts. Although vardenafil was protective at 10nM, we were surprised to find that the protective effect was lost at higher concentrations. So far, we have no explanation for this observation. We could show that protection by vardenafil at 10nM was dependent on the activity of GC and the cGMP-dependent kinase PKG. Furthermore, vardenafil was found to be protective in a model of TMRE-stained cardiomyocytes exposed to calcium stress with a selective calcium ionophore. The cell model allowed the additional use of the highly specific PKG inhibitory peptides DT-2 and DT-3 to further support a role for PKG.

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