Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Conclusion
The primary outcome parameter, FEV1 at 5 min, showed no difference between formoterol and terbutaline. At 5 min after dosing, the mean increase from each predrug baseline was 62% of the maximum increase for each drug. The median recovery times for for-moterol, terbutaline, and placebo were 5.0 min, 7.4 min, and 44 min, respectively. Similar numbers of standard dose inhalations of formoterol (4.5 ^g) and terbutaline (0.5 mg) gave less systemic activity from formoterol.
EIB is a cardinal symptom in pediatric asthma affecting social and physical development and quality of life more so than in adults. Asthma management strategies today generally recommend the use of SABAs 15 min before exercise. This may be well suited for the scheduled activities of adult life, but it is insufficient for most children. Typically, children exercise spontaneously multiple times during a day, and such repeated pretreatment is a challenge to compliance. Prolonged protection should be preferred to enhance the child’s physical activity.