Category: Asthma

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Conclusion

The primary outcome parameter, FEV1 at 5 min, showed no difference between formoterol and terbutaline. At 5 min after dosing, the mean increase from each predrug baseline was 62% of the maximum increase for each drug. The median recovery times for for-moterol, terbutaline, and placebo were 5.0 min, 7.4 min, and 44 min, respectively. Similar…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Discussion

An unexpected result was that the drop in lung function before drug administration on the formot-erol day was statistically significantly smaller than on the placebo day with the drop on the terbutaline day in-between. Baseline antiinflammatory treatment was unchanged, and the analysis revealed no period or carryover effect, so this appears a chance finding and…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: FEVj

FEV1 before (baseline) and 5 min after (predose) exercise are shown in Table 2 together with the percentage drop between these two time points. The drop during the formoterol day (26.4%) most resembled the drop during the screening day (25.5%) but was statistically significantly smaller than during the placebo day (37.3%; p = 0.001). The…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Patients Enrolled

Carryover effects for predose FEV1 were investigated graphically. The baseline value of the study day and the predose value (5 min after exercise) were both used as covariates in the analysis. Time to recovery (time from drug administration until FEV1 had reached within 5% of baseline FEV1) was compared between active treatments using Wilcoxon signed…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Statistics

Spirometry was performed and results accepted as per American Thoracic Society (ATS) standards (Jaeger MasterScreen; E Jaeger GmbH; Wurzburg, Germany) with the children in a sitting position wearing a nose clip. FEV1 and maximal mid-expiratory flow (MMEF25-75) were recorded before exercise (baseline), after exercise (1 min, 3 min, and 5 min), and after administration of…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma: Materials and Methods

The study was performed in accordance with the declaration of Helsinki and approved by the local ethics committee (KF 02-082/00) and the Danish Medicines Agency (2612-1507). Before enrollment, informed consent was obtained from both children and parents/legal guardians. Patients were recruited from two pediatric outpatient clinics in Copenhagen. Children 7 to 15 years old with…

Acute Relief of Exercise-Induced Bronchoconstriction by Inhaled Formoterol in Children With Persistent Asthma

Relief therapy is pivotal to any asthma management plan. The aims of such a therapy are rapid lung function improvement and preferably prolonged action with the option of repeated dosing without risk of side effects. In addition, bronchopro-tection against asthma triggers such as exercise is desired. add comment Inhaled formoterol is a full (32-agonist. Onset…

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