Vardenafil demonstrates first-dose success and reliability of penetration and maintenance of erection in men with erectile dysfunction. Introduction
Erectile dysfunction (ED) is a highly prevalent condition that has a major impact on the lives of millions of men and their partners, affecting sexual and psychological health and quality of life (QOL). Depending on the etiology, ED may indicate underlying systemic vascular or neurogenic disease that is often associated with the impairment of neurogenic and/or endothelium-dependent vasodilatory mechanisms, which in turn contribute to circulatory and structural changes in penile tissues. The resulting arterial insufficiency and defective smooth muscle relaxation in men with vascular comorbidities lead to an increased prevalence of ED in this patient population, which complicates disease management.