Category: Migraine

The Relationship Between Migraine and Right-to-Left Shunt: Pathophysiologic Hypothesis

Different pathophysiologic hypotheses have been proposed to explain these findings. Firstly, trigger substances might enter the systemic circulation through the right-to-left shunt instead of being trapped in the pulmonary capillaries. These trigger substances could induce cerebral vascular instability or increased excitability of the CNS and provoke migraine attacks. In individuals without a right-to-left shunt or…

The Relationship Between Migraine and Right-to-Left Shunt: Migraine Criteria

In contrast, Yankovsky and Kuritzky reported aggravation of migraine with aura into a daily pattern after closure of an ASD in a single patient. The latter was also suggested by Mortelmans et al, who found an aggravation of migraine with aura after percutaneous ASD closure with relatively larger Amplatzer ASD devices. However, the reason for…

The Relationship Between Migraine and Right-to-Left Shunt: Shunt Closure and Migraine

We and others> have described the changes in prevalence of migraine after percutaneous PFO closure. These data are summarized in Table 1. All studies, except for the study by Schw-erzmann et al, showed a significant reduction in the prevalence of migraine and migraine with aura after percutaneous PFO closure. The relative reduction in prevalence of…

The Relationship Between Migraine and Right-to-Left Shunt: Occurrence of Right-to-Left Shunt and Migraine

In patients with migraine, the prevalence of a right-to-left shunt seems to be higher when compared to the general population. Two investigational groups used transcranial Doppler ultrasound to determine right-to-left shunts in patients with migraine. A right-to-left shunt was found in 23% of the patients with migraine without aura. Forty-one to 48% of the patients…

The Relationship Between Migraine and Right-to-Left Shunt: Patent Foramen Ovale

The most common origin of a right-to-left shunt is the patent foramen ovale (PFO). The PFO is an important feature of fetal circulation. The interatrial septum primum on the left side and the interatrial septum secundum on the right side maintain a central communication before birth, so that blood bypasses the pulmonary circulation. After birth,…

The Relationship Between Migraine and Right-to-Left Shunt

Migraine is a very common type of headache, affects the quality of life importantly, and has been ranked among the most disabling medical illnesses in the world. Migraine seems to be a complex disorder in which genetic, environmental, behavioral, and other as-yet unidentified factors interact to trigger the typical migraine attacks. A causal relationship between…