Effect of Disodium Cromoglycate on Ventilation and Gas Exchange During Exercise in Asthmatic Children With a Postexertion FEVi Fall Less Than 15 Percent: Study Subjects


The children suffered from mild to moderate asthma with a duration of disease of 1 to 13 (7.5 ±3) years. All patients had a typical history of episodic breathlessness and wheezing and relief of symptoms with use of bronchodilators. None of the children was limited in daily life because of the disease, and most of them were engaged in a regular physical activity. Thirteen children had a positive skin prick test to one or more allergens—(Dermatoph-agoides pteronyssinus, Dermatophagoides farinae, grass pollen). A history of atopic dermatitis was present in three patients. At the time of the study, the usual therapy was DSCG in six children and beclomethasone dipropionate in two children. All medication was withdrawn at least 24 h before testing.
In order to evaluate a possible effect of inhaled DSCG in normal subjects, nine healthy children (five males and four females) underwent the same exercise protocol. They were recruited from local schools and were not matched with the asthmatic patients. In this group, the age range was 7 to 15 (11 ± 2.6) years. They had no history of asthma, atopy, or other respiratory disorders.
The parents gave informed consent for their children to participate, and the study was approved by our Institutional Review Board in detail zyrtec tablets.
The children underwent two maximal exercise tests on a treadmill (PK Morgan Ltd, Gillingham, Kent, United Kingdom) in a stable laboratory environment (temperature, 21 to 24°C; humidity, 50 to 70 percent). The two tests were performed in the afternoon, at least 2 h after a meal, in a randomized order on different days (within 10 days): test A (baseline) was done without premedication (empty capsules) and test B, after inhalation of DSCG. In test B, two capsules (40 mg) of DSCG were inhaled via a Spinhaler 30 min before exercise.