News (Page 34)

Managing the Low-Socioeconomic-Status Prostate Cancer Patient: INTRODUCTION

Management of patients with prostate cancer may include “watchful waiting,” hormonal (androgen ablative) therapy, radical prostatectomy, cryosurgery, chemotherapy or radiation therapy in the form of external-beam radiotherapy, high-dose radiotherapy or brachytherapy. While clinical variables, such as age, disease stage, prostate-specific antigen (PSA) level, Gleason score, comorbidities and symptoms, are important considerations in the physicians’ selection…

What’s new

This is the first clinical study in which a stopwatch approach was used to measure accurately the duration of erection as it pertains to successful intercourse during PDE5 inhibitor therapy. Results demonstrate that treatment with vardenafil (Levitra) is associated with an increased duration of erection and restoration of erectile function compared with placebo.

Dosage

Dosage and Administration It is recommended to take an oral dose of LEVITRA 25 mins to 1 hour before engaging in sexual acts. 10 mg is the advsed starting dose for LEVITRA. A patient can commence with sex acts as early as 15 minutes post taking LEVITRA and as late as 4-5 hours. It is…

Interactions shown not to exist

Glibenclamide The relative bioavailability of glibenclamide was not affected with 3.5 mg of glibenclamide was co-administered with 20mg of vardenafil (there was no effect on glibenclamide’s AUC or Cmax). Warfarin The co-administration of warfarin with vardenafil did not effect vardenafil’s pharmacokinetics. When 25 mg of warfarin was co-administered with 20 mg of vardenafil no pharmacokinetic…

Potential Interactions

CYP 3A4 Inhibitors Using the CYP 3A4 inhibitors itraconazole and ritonavir with vardenafil will most likely be responsible for plasma levels similar to indinavir and ketoconazole (In Demonstrated Interactions). High plasma levels will not only increase effectiveness but increase occasions of adverse events. Never take more than a 5 mg dose of vardenafil when combining…

Demonstrated Interactions

Erythromycin Fit voluteers experience a increase of 4-fold vardenafil AUC and 3-fold in Cmax when vardenafil (5 mg) was taken with a CYP3A4 inhibitor called Erythromycin 500 mg t.i.d.. Never take more than a 5 mg dose of vardenafil when combining it with the use of generic erythromycin. Ketoconazole Fit voluteers experience a increase of…

Precautions

Cardiovascular Disease There is some element of cardiac risk involved in sexual activity, therefore physicians must take a look their patients cardiovascular condition before prescribing erectile dysfunction treatment. Other Pre-existing Medical Conditions Patients with anatomically deforming penis conditions (like cavernosal fibrosis, angulation, or Peyronie’s disease) or with condition that might induce priapism (like leukemia, sickle…

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