News (Page 35)

Contraindications

Vardenafil’s contraindications are found in patients who are known to be highly sensitive any of the drugs ingredients, active or inactive. Canadian Vardenafil and Nitrates must not be used together. Using drugs vardenafil with nitric oxide donors, organic nitrites, or organic nitrate is contraindicated, whether it is used occasionally of regularly. A list of other…

Pharmacokinetics in Special Populations

Elderly In healthy elderly volunteers, 65 years +, vardenafil’s half-life did not suffer a notable reduction from that or younger voulunteers (45 years and younger). There is a 52% higher AUC in the average elderly male than that of a younger male, that is within a clinical trials observed variability. Placebo monitored clinical trials produced…

Pharmacokinetics

Absorption After being applied orally, Vardenafil (Levitra) is quickly absorbed. 90% of patients reach Cmax, on an empty stomach, between 30 to 120 mins (median 1 hour) after oral dosing, but Cmax has been achieved as soon as 15 minutes in others. Observed pharmacokinetic parameters have a substantial intra-subject and inter-subject variability caused by vardenafil’s…

Effects

Effects on Visual Perception In one particular clinical trial, Visual fields, visual acuity, ERG latency, intraocular pressure, fundoscopic, nor slit lamp findings showed signs of being effected when visual functions were tested after a 40mg dose of vardenafil (two times the maximum recommended daily dosage). A minor group of patients spoke of color distortions in…

Pharmacology

The haemodynamic process of erecting a penis is grounded in the relaxation of smooth muscle in the corpus cavernosum and its allied arterioles. Nitric oxide (NO) is released from the corpus cavernosum’s nerve ends during sexual arousal. This triggers the enxyme guanylate cyclase causing the corpus cavernosum’s cyclic guanosine monophosphate (cGMP) levels to increase. This…

LEVITRA® Tablets (Vardenafil, BAYER)

Name of the Drug Vardenafil (CAS number: 224785-90-4) in the form of vardenafil hydrochloride trihydrate. The empirical formula of vardenafil hydrochloride trihydrate: C23H32N6O4S.HCI.3H2O. Molecular weight: 579.1 g/mol. Description Vardenafil hydrochloride trihydrate, a nearly colorness solid, is 2-[ethoxy-5-(4-ethyl-piperazine-1-sulfonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride trihydrate. Vardenafil hydrochloride trihydrate is soluble in 0.1M HCI and ethanol, freely soluble in methanol, and only…

Levitra Ingredients

What it Looks Like Levitra 5 mg tablets are orange film-coated round tablets with an embossed BAYER-cross on one side and “5” on the other side (sold in blister packs of 2 and 4). Levitra 10 mg tablets are orange film-coated round tablets with an embossed BAYER-cross on one side and “10” on the other…

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