Potential Interactions
Using the CYP 3A4 inhibitors itraconazole and ritonavir with vardenafil will most likely be responsible for plasma levels similar to indinavir and ketoconazole (In Demonstrated Interactions). High plasma levels will not only increase effectiveness but increase occasions of adverse events. Never take more than a 5 mg dose of vardenafil when combining it with the use of itraconazole, ketaconazole, and erythromycin. It is advised to avoid combination use of the HIV protease inhibitors indinavir or ritonavir with canadian vardenafil.
Nitrates/Nitric Oxide Donors
Data concerning the potential hypotensive effects of vardenafil when combined with use of nitrates is limited. Concomitant use is contraindicated due to experience with patients suffering clinically significant hypotension with co-administration of other PDE5 inhibitors. (In CONTRAINDICATIONS).
Avoid using nitrates until no less than 24 hours (~5 half-lives), after the last time you have taken vardenafil. If you have been using concomitant drugs, like CYP3A4 inhibitors, which injure the metabolism of drug vardenafil, you should observe an extended wash out period.
Information concerning the combined use of antihypertensive agents ant vardenafil is limited. Notable effects of ACE-inhibitors, diuretics, or beta-blockers on vardenafil’s pharmacokinetics were not uncovered by population pharmacokinetic investigations of phase III data. The potential for additive hypotensive effects still remains so, until more is know about the combination, use cautions when co-administering antihypertensive agents with vardenafil (levitra).
Add A Comment